Imipramine hydrochloride

Name: Imipramine hydrochloride
Brand: Tocris Bioscience
SKU: 7841

Tocris Bioscience, part of Bio-Techne | Catalog # 7841

Citations (1)

COA / SDS

Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment

Key Product Details

Description:	Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment
Chemical Name:	5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	316.87

View Full Technical Details for Imipramine hydrochloride

Technical Data
Citations

Biological Activity for Imipramine hydrochloride

Imipramine hydrochloride is a potent tricyclic antidepressant; inhibits 5-HT and noradrenalin transporters (K_i values = 1.3-20 nM and 20-142 nM respectively). Increases autophagy, both alone and in combination with VEGF inhibitors or Temozolomide (Cat. No. 2706), to reduce the progression of glioma and slow the proliferation of other tumors. Reprograms tumor-associated macrophages from immunosuppressive to immunostimulatory via histamine receptor inhibition.

Compound Libraries for Imipramine hydrochloride

Imipramine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Imipramine hydrochloride

M. Wt	316.87
Formula	C₁₉H₂₄N₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	113-52-0
PubChem ID	8228
InChi Key	XZZXIYZZBJDEEP-UHFFFAOYSA-N
Smiles	CN(C)CCCN(C1=C(CC2)C=CC=C1)C3=C2C=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Imipramine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	15.84	50
	water	15.84	50

Preparing Stock Solutions for Imipramine hydrochloride

The following data is based on the product molecular weight 316.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.31 mL	31.56 mL	63.12 mL
2.5 mM	1.26 mL	6.31 mL	12.62 mL
5 mM	0.63 mL	3.16 mL	6.31 mL
25 mM	0.13 mL	0.63 mL	1.26 mL

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References for Imipramine hydrochloride

References are publications that support the biological activity of the product.

Chryplewicz Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell 2022 PMID: 36113478
Wang Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide. J.Cell.Mol.Med. 2021 PMID: 34469035