IND 1316

Name: IND 1316
Brand: Tocris Bioscience
SKU: 7685

Tocris Bioscience, part of Bio-Techne | Catalog # 7685

COA / SDS

AMPK activator

Key Product Details

Description:	AMPK activator
Chemical Name:	3-[3-(Phenylmethoxy)phenyl]-1H-indole-2-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	343.38

View Full Technical Details for IND 1316

Technical Data
Citations

Biological Activity for IND 1316

IND 1316 is an activator of AMP-activated protein kinase (AMPK). In vitro, it activates AMPK in a dose-dependent manner and induces different MAPK pathways (p38 and JNK). In vivo, it reduces the neuropathological symptoms in two animal models of Huntington's Disease (nematodes and mice). It shows very low toxicity even at high concentrations (>200 μM). This compound is orally bioavailable.

Technical Data for IND 1316

M. Wt	343.38
Formula	C₂₂H₁₇NO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1888473-12-8
PubChem ID	130234214
InChi Key	WFARYZNGGCHILS-UHFFFAOYSA-N
Smiles	OC(C1=C(C2=CC(OCC3=CC=CC=C3)=CC=C2)C4=CC=CC=C4N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IND 1316

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.34	100
	ethanol	34.34	100

Preparing Stock Solutions for IND 1316

The following data is based on the product molecular weight 343.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.56 mL	29.12 mL
5 mM	0.58 mL	2.91 mL	5.82 mL
10 mM	0.29 mL	1.46 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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Reconstitution Calculator

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References for IND 1316

References are publications that support the biological activity of the product.

Vela Neuroprotective effect of IND1316, an indole-based AMPK activator, in animal models of Huntington disease. ACS Chem.Neurosci. 2022 PMID: 34962383