Indinavir sulfate

Name: Indinavir sulfate
Brand: Tocris Bioscience
SKU: 7196

Tocris Bioscience, part of Bio-Techne | Catalog # 7196

Citations (2)

COA / SDS

Potent and selective HIV-1 and HIV-2 protease inhibitor

Key Product Details

Description:	Potent and selective HIV-1 and HIV-2 protease inhibitor
Chemical Name:	2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate
Purity:	≥98% (HPLC)
Molecular Weight:	711.88

View Full Technical Details for Indinavir sulfate

Technical Data
Citations

Biological Activity for Indinavir sulfate

Indinavir sulfate is a potent and selective HIV protease inhibitor (K_i values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CL^pro.

Technical Data for Indinavir sulfate

M. Wt	711.88
Formula	C₃₆H₄₇N₅O₄.H₂SO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	157810-81-6
PubChem ID	5462355
InChi Key	NUBQKPWHXMGDLP-BDEHJDMKSA-N
Smiles	S(=O)(=O)(O)O.N(C([C@H](CC1=CC=CC=C1)C[C@@H](CN2[C@H](C(NC(C)(C)C)=O)CN(CC=3C=CC=NC3)CC2)O)=O)[C@H]4C=5C(C[C@H]4O)=CC=CC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Indinavir sulfate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	71.19	100
	water	71.19	100

Preparing Stock Solutions for Indinavir sulfate

The following data is based on the product molecular weight 711.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.40 mL	7.02 mL	14.05 mL
5 mM	0.28 mL	1.40 mL	2.81 mL
10 mM	0.14 mL	0.70 mL	1.40 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

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References for Indinavir sulfate

References are publications that support the biological activity of the product.

Hall A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med.Infect.Dis. 2020 PMID: 32294562
Brown Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C₂C₁₂ myocytes. Am.J.Physiol.Cell Physiol. 2004 PMID: 15229102
Brown Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am.J.Physiol.Endocrinol.Metab. 2005 PMID: 15827064
Dorsey L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor. J.Med.Chem. 1994 PMID: 7932573