Ionomycin calcium salt

Name: Ionomycin calcium salt
Brand: Tocris Bioscience
SKU: 1704

Tocris Bioscience, part of Bio-Techne | Catalog # 1704

(3)

Citations (29)

COA / SDS

Calcium ionophore

Key Product Details

Chemical Name:	(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt
Purity:	≥97%
Molecular Weight:	747.08 kDa

View Full Technical Details for Ionomycin calcium salt

Technical Data
Citations / Reviews (3)

Biological Activity for Ionomycin calcium salt

Ionomycin calcium salt is a calcium ionophore; more specific than A23187.

Free Acid also available.

Technical Data for Ionomycin calcium salt

M. Wt	747.08 kDa
Formula	C₄₁H₇₀O₉.Ca
Storage	Store at -20°C
Purity	≥97%
CAS Number	56092-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ionomycin calcium salt

Solubility

Soluble Soluble to 100 mM in ethanol and to 25 mM in DMSO with gentle warming

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References for Ionomycin calcium salt

References are publications that support the biological activity of the product.

Y Deng, X Xia, Y Zhao, Z Zhao, C Martinez, W Yin, J Yao, Q Hang, W Wu, J Zhang, Y Yu, W Xia, F Yao, D Zhao, Y Sun, H Ying, MC Hung, L Ma Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance Nature Communications, 2021;12(1):7041. 2021 PMID: 34873175
Selway J, Rigatti R, Storey N, Lu J, Willars GB, Herbert TP Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1. PLoS ONE, 2012;7(3):e33004. 2012 PMID: 22412973
Liu and Hermann Characterization of ionomycin as a calcium ionophore. J.Biol.Chem., 1978;253:5892 PMID: 28319
Kaufmann et al. Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J.Biol.Chem., 1980;255:2735 PMID: 6766939
Elzi et al. Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. Am.J.Physiol.Cell Physiol., 2001;281:C350 PMID: 11401859