Irbesartan

Name: Irbesartan
Brand: Tocris Bioscience
SKU: 5798

Tocris Bioscience, part of Bio-Techne | Catalog # 5798

COA / SDS

Potent AT1 antagonist

Key Product Details

Description:	Potent AT₁ antagonist
Chemical Name:	2-Butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	428.53

View Full Technical Details for Irbesartan

Technical Data
Citations

Biological Activity for Irbesartan

Irbesartan is a potent angiotensin II type 1 receptor (AT₁) antagonist (IC₅₀ = 1.3 nM). Displays antihypertensive activity. Orally bioavailable.

Compound Libraries for Irbesartan

Irbesartan is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Irbesartan

M. Wt	428.53
Formula	C₂₅H₂₈N₆O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	138402-11-6
PubChem ID	3749
InChi Key	YOSHYTLCDANDAN-UHFFFAOYSA-N
Smiles	O=C(C1(CCCC1)N=C2CCCC)N2CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Irbesartan

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.85	100
	ethanol	4.29	10

Preparing Stock Solutions for Irbesartan

The following data is based on the product molecular weight 428.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Molarity Calculator

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Reconstitution Calculator

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References for Irbesartan

References are publications that support the biological activity of the product.

Burnier Angiotensin II type 1 receptor blockers. Circulation 2001 PMID: 11171802