Ischemin sodium salt

Name: Ischemin sodium salt
Brand: Tocris Bioscience
SKU: 4695

Tocris Bioscience, part of Bio-Techne | Catalog # 4695

Citations (7)

COA / SDS

CBP inhibitor; cell permeable

Key Product Details

Description:	CBP inhibitor; cell permeable
Chemical Name:	5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium salt
Purity:	≥99% (HPLC)
Molecular Weight:	357.36

View Full Technical Details for Ischemin sodium salt

Technical Data
Citations

Biological Activity for Ischemin sodium salt

Ischemin sodium salt is a CBP bromodomain inhibitor. Inhibits p53 interaction with CBP and decreases p53 transcriptional activity. Protects against Doxorubicin-induced apoptosis in cardiomyocytes in vitro. Cell permeable.

Technical Data for Ischemin sodium salt

M. Wt	357.36
Formula	C₁₅H₁₆N₃O₄SNa
Storage	Store at +4°C
Purity	≥99% (HPLC)
PubChem ID	64983
InChi Key	XWNMORIHKRROGW-UHFFFAOYSA-N
Smiles	CC1=CC(/N=N/C2=C(C)C=C(C)C(S(=O)(O[Na])=O)=C2)=C(N)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ischemin sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	35.74	100
	DMSO	35.74	100

Preparing Stock Solutions for Ischemin sodium salt

The following data is based on the product molecular weight 357.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.80 mL	13.99 mL	27.98 mL
5 mM	0.56 mL	2.80 mL	5.60 mL
10 mM	0.28 mL	1.40 mL	2.80 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for Ischemin sodium salt

References are publications that support the biological activity of the product.

Borah A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem.Biol. 2011 PMID: 21513889