ISO 1

Biological Activity for ISO 1

Technical Data for ISO 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ISO 1

References for ISO 1

References are publications that support the biological activity of the product.

• I Cotzomi-Or, A Rosas-Cruz, D Ramírez-Ra, J Reyes-Leyv, M Rodriguez-, P Aguilar-Al, P Maycotte Autophagy Inhibition Induces the Secretion of Macrophage Migration Inhibitory Factor (MIF) with Autocrine and Paracrine Effects on the Promotion of Malignancy in Breast Cancer Biology (Basel), 2020;9(1):. 2020 PMID: 31963754
• L Rijvers, MJ Melief, RM van der Vu, M Stéphant, J van Langel, AF Wierenga-W, JM Hogervorst, AJ Geurts-Moe, FCGJ Sweep, RQ Hintzen, MM van Luijn The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis Eur. J. Immunol., 2018;0(0):. 2018 PMID: 30160778
• Lubetsky et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J.Biol.Chem., 2002;277:24976 PMID: 11997397
• Al-Abed et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J.Biol.Chem., 2005;280:36541 PMID: 16115897
• Cvetkovic et al. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology, 2005;146:2942 PMID: 15790730
• Chen et al. ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma. Mol.Med., 2010;16:400 PMID: 20485865