Isradipine

Name: Isradipine
Brand: Tocris Bioscience
SKU: 2004

Tocris Bioscience, part of Bio-Techne | Catalog # 2004

Citations (472)

COA / SDS

CaV1.x blocker

Key Product Details

Description:	Ca_V1.x blocker
Alternative Names:	PN 200-110
Chemical Name:	4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	371.39

View Full Technical Details for Isradipine

Technical Data
Citations

Biological Activity for Isradipine

Isradipine is a potent and selective L-type voltage-gated Ca²⁺ channel blocker. EC₅₀ and pA₂ values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca²⁺-induced contractions of rabbit aorta respectively; EC₂₅ = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.

Compound Libraries for Isradipine

Isradipine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Isradipine

M. Wt	371.39
Formula	C₁₉H₂₁N₃O₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	75695-93-1
PubChem ID	3784
InChi Key	HMJIYCCIJYRONP-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Isradipine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.57	50
	ethanol	7.43	20

Preparing Stock Solutions for Isradipine

The following data is based on the product molecular weight 371.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.39 mL	26.93 mL	53.85 mL
2.5 mM	1.08 mL	5.39 mL	10.77 mL
5 mM	0.54 mL	2.69 mL	5.39 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

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References for Isradipine

References are publications that support the biological activity of the product.

Wada Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart. J.Cardiovasc.Pharmacol. 1985 PMID: 2580142
Ruegg and Hof Pharmacology of the calcium antagonist israd. Drugs
Hof PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. J.Cardiovasc.Pharmacol. 1984 PMID: 6202964