Ivermectin

Name: Ivermectin
Brand: Tocris Bioscience
SKU: 1260
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1260

(1)

Citations (29)

COA / SDS

Positive allosteric modulator of α7 nAChRs; also positive allosteric modulator of P2X4 receptors

Key Product Details

Description:	Positive allosteric modulator of α7 nAChRs; also positive allosteric modulator of P2X₄ receptors
Chemical Name:	22,23-Dihydroavermectin B1
Purity:	≥96% (HPLC)
Molecular Weight:	875.1

View Full Technical Details for Ivermectin

Technical Data
Citations / Reviews (1)

Biological Activity for Ivermectin

Ivermectin is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X₄ receptor. Antihelmintic and antiviral. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). Inhibits replication of SARS-CoV-2 in vitro (IC₅₀ ~ 2μM).

This product is composed of both Ivermectin B_1a (>90%) and Ivermectin B_1b.

Technical Data for Ivermectin

M. Wt	875.1
Formula	C₄₈H₇₄O₁₄ (B₁a form)
Storage	Desiccate at +4°C
Purity	≥96% (HPLC)
CAS Number	70288-86-7
PubChem ID	6321424
InChi Key	AZSNMRSAGSSBNP-XPNPUAGNSA-N
Smiles	O[C@H]1[C@H](C)O[C@](O[C@H]2[C@@H](O[C@](O[C@H](/C(C)=C/C[C@@]4([H])O[C@@]7(CC[C@H](C)[C@@]([H])([C@]([H])(C)C)O7)C[C@@H]6C4)[C@@H](C)/C=C/C=C3/[C@]5(O)[C@]([C@H](O)C(C)=CC5C(O6)=O)([H])OC3)([H])C[C@@H]2OC)C)([H])C[C@@H]1OC.O[C@H]8[C@H](C)O[C@](O[C@H]9[C@@H](O[C@](O[C@H](/C(C)=C/C[C@@]%11([H])O[C@@]%14(CC[C@H](C)[C@@]([H])([C@]([H])(C)CC)O%14)C[C@@H]%13C%11)[C@@H](C)/C=C/C=C%10/[C@]%12(O)[C@]([C@H](O)C(C)=CC%12C(O%13)=O)([H])OC%10)([H])C[C@@H]9OC)C)([H])C[C@@H]8OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ivermectin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		50

Preparing Stock Solutions for Ivermectin

The following data is based on the product molecular weight 875.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.29 mL	11.43 mL	22.85 mL
2.5 mM	0.46 mL	2.29 mL	4.57 mL
5 mM	0.23 mL	1.14 mL	2.29 mL
25 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for Ivermectin

References are publications that support the biological activity of the product.

Caly The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 2020 PMID: 32251768
Shan Ivermectin, an unconventional agonist of the glycine receptor chloride channel. J.Biol.Chem. 2001 PMID: 11278873
Khakh Allosteric control of gating and kinetics at P2X₄ receptor channels. J.Neurosci. 1999 PMID: 10460235
Krause Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol.Pharmacol. 1998 PMID: 9463487
Adelsberger Activation of rat recombinant α1β2γ2S GABA_A receptor by the insecticide iverm. Eur.J.Pharmacol. 2000 PMID: 10771281