J 147

Name: J 147
Brand: Tocris Bioscience
SKU: 5081

Tocris Bioscience, part of Bio-Techne | Catalog # 5081

Citations (1)

COA / SDS

Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels

Key Product Details

Description:	Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
Chemical Name:	2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Purity:	≥99% (HPLC)
Molecular Weight:	350.33

View Full Technical Details for J 147

Technical Data
Citations

Biological Activity for J 147

J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC₅₀ = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

Licensing Information

Sold for research use only under license from the Salk Institute for Biological Studies

Compound Libraries for J 147

J 147 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for J 147

M. Wt	350.33
Formula	C₁₈H₁₇F₃N₂O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1146963-51-0
PubChem ID	25229652
InChi Key	HYMZAYGFKNNHDN-SSDVNMTOSA-N
Smiles	O=C(C(F)(F)F)N(C2=C(C)C=C(C)C=C2)/N=C/C1=CC=CC(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for J 147

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.03	100
	ethanol	35.03	100

Preparing Stock Solutions for J 147

The following data is based on the product molecular weight 350.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.27 mL	28.54 mL
5 mM	0.57 mL	2.85 mL	5.71 mL
10 mM	0.29 mL	1.43 mL	2.85 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for J 147

References are publications that support the biological activity of the product.

Prior The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimer's.Res.Ther. 2013 PMID: 23673233
Chiruta Metabolism of a potent neuroprotective hydrazide. Bioorg.Med.Chem. 2013 PMID: 23582448
Chen A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One 2011 PMID: 22194796