J 2156

Name: J 2156
Brand: Tocris Bioscience
SKU: 6201

Tocris Bioscience, part of Bio-Techne | Catalog # 6201

Citations (2)

COA / SDS

Selective high affinity human sst4 agonist

Key Product Details

Description:	Selective high affinity human sst₄ agonist
Chemical Name:	(1'S,2S)-4-Amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4"-methyl-1"-naphthalenesulfonylamino)butanamide trifluoroacetate
Purity:	≥98% (HPLC)
Molecular Weight:	582.6

View Full Technical Details for J 2156

Technical Data
Citations

Biological Activity for J 2156

J 2156 is a high affinity human somatostatin receptor 4 (sst₄) agonist (K_i = 1.2 nM). Displays >400-fold selectivity for human sst₄ over other human sst receptor subtypes. Exhibits 2 to 3-fold more potent agonism in vitro than endogenous ligands somatostatin-14 (Cat. No. 1157) and somatostatin-28 (Cat. No. 1165). Reduces inflammatory airway hyperresponsiveness in acute and chronic airway inflammation models in mice. Exhibits anxiolytic effects in elevated plus maze test in mice.

Compound Libraries for J 2156

J 2156 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for J 2156

M. Wt	582.6
Formula	C₂₄H₂₈N₄O₄S.C₂HF₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2387505-73-7
PubChem ID	11442741
InChi Key	VTNCZBXJSGKDLS-SFTDATJTSA-N
Smiles	CC1=CC=C(S(=O)(N[C@H](C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)CCN)=O)C3=C1C=CC=C3.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for J 2156

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	58.26	100
	DMSO	58.26	100

Preparing Stock Solutions for J 2156

The following data is based on the product molecular weight 582.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.72 mL	8.58 mL	17.16 mL
5 mM	0.34 mL	1.72 mL	3.43 mL
10 mM	0.17 mL	0.86 mL	1.72 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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References for J 2156

References are publications that support the biological activity of the product.

Elekes Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 2008 PMID: 17961545
Scheich Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models. Neuropharmacology. 2016 PMID: 26387439
Engström Superagonism at the human somatostatin receptor subtype 4. J.Pharmacol.Exp.Ther. 2005 PMID: 15333679