Jasplakinolide

Name: Jasplakinolide
Brand: Tocris Bioscience
SKU: 2792

Tocris Bioscience, part of Bio-Techne | Catalog # 2792

Citations (60)

COA / SDS

Stabilizes F-actin; promotes actin polymerization

Key Product Details

Description:	Stabilizes F-actin; promotes actin polymerization
Chemical Name:	Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
Purity:	≥97% (HPLC)
Molecular Weight:	709.67

View Full Technical Details for Jasplakinolide

Technical Data
Citations

Biological Activity for Jasplakinolide

Jasplakinolide rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (K_d ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC₅₀ = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

Technical Data for Jasplakinolide

M. Wt	709.67
Formula	C₃₆H₄₅BrN₄O₆
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	102396-24-7
PubChem ID	9831636
InChi Key	GQWYWHOHRVVHAP-DHKPLNAMSA-N
Smiles	C[C@H](C[C@H](C)OC1=O)/C=C(C)/C[C@H](C)C(N[C@H](C(N([C@H](CC2=C(Br)NC3=C2C=CC=C3)C(N[C@@H]([C@]4=CC=C(O)C=C4)C1)=O)C)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Jasplakinolide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2

Preparing Stock Solutions for Jasplakinolide

The following data is based on the product molecular weight 709.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.03 mM	46.97 mL	234.85 mL	469.70 mL
0.15 mM	9.39 mL	46.97 mL	93.94 mL
0.3 mM	4.70 mL	23.49 mL	46.97 mL
1.5 mM	0.94 mL	4.70 mL	9.39 mL

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References for Jasplakinolide

References are publications that support the biological activity of the product.

Bubb Effects of jasplakinolide on the kinetics of actin polymerization. J.Biol.Chem. 2000 PMID: 10671562
Bubb Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J.Biol.Chem. 1995 PMID: 8195116
Cramer Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide. Curr.Biol. 1999 PMID: 10531004