JBJ-03-142-02

Name: JBJ-03-142-02
Brand: Tocris Bioscience
SKU: 6962

Tocris Bioscience, part of Bio-Techne | Catalog # 6962

COA / SDS

Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors

Key Product Details

Description:	Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors
Chemical Name:	(4-Fluorophenyl)methyl N-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	487.5

View Full Technical Details for JBJ-03-142-02

Technical Data
Citations

Biological Activity for JBJ-03-142-02

JBJ-03-142-02 is a highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor. Inhibits wild type and tumorgenic mutated receptors (exon 20 insertion; Ex20Ins). Antiproliferative in vitro (IC₅₀ values are 7.6, 30 - 95, 3.8 and 19 - 31 nM for Ba/F3 cells expressing wild type EGFR, EGFR with Ex20Ins mutation, wild type HER2 and HER2 with Ex20Ins mutation, respectively). Also inhibits other common EGFR mutants. Antiproliferative in patient-derived lung cancer cell lines.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for JBJ-03-142-02

M. Wt	487.5
Formula	C₂₅H₂₂FN₇O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2068806-31-3
PubChem ID	126496758
InChi Key	IFRXGTCPIGRGHP-UHFFFAOYSA-N
Smiles	CN1C=C(NC2=NC=CC(=N2)N(C(=O)OCC2=CC=C(F)C=C2)C2=CC(NC(=O)C=C)=CC=C2)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JBJ-03-142-02

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	24.37	50

Preparing Stock Solutions for JBJ-03-142-02

The following data is based on the product molecular weight 487.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.10 mL	20.51 mL	41.03 mL
2.5 mM	0.82 mL	4.10 mL	8.21 mL
5 mM	0.41 mL	2.05 mL	4.10 mL
25 mM	0.08 mL	0.41 mL	0.82 mL

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References for JBJ-03-142-02

References are publications that support the biological activity of the product.

Jang Discovery of a highly potent and broadly effective epidermal growth factor receptor and HER2 exon 20 insertion mutant inhibitor. Angew.Chem.Int.Ed.Engl. 2018 PMID: 29978938

Product Documents for JBJ-03-142-02

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.