JMS 17-2 hydrochloride

Name: JMS 17-2 hydrochloride
Brand: Tocris Bioscience
SKU: 6378

Tocris Bioscience, part of Bio-Techne | Catalog # 6378

Citations (1)

COA / SDS

CX3CR1 antagonist

Key Product Details

Chemical Name:	5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride
Purity:	≥98%

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Technical Data
Citations

Biological Activity for JMS 17-2 hydrochloride

JMS 17-2 hydrochloride is a chemokine CX3CR1 (fractalkine receptor) antagonist. Inhibits fractalkine-induced ERK phosphorylation and decreases migration of breast cancer cells in vitro. Also inhibits circulating tumor cells from seeding into bone and reduces overall tumor burden in a breast cancer metastasis model.

Technical Data for JMS 17-2 hydrochloride

Formula	C₂₅H₂₆ClN₃O.HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	2341841-07-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JMS 17-2 hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for JMS 17-2 hydrochloride

References are publications that support the biological activity of the product.

Shen et al. Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells. Mol. Cancer Res., 2016;14:518 PMID: 27001765

JMS 17-2 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6378

Key Product Details

Biological Activity for JMS 17-2 hydrochloride

Technical Data for JMS 17-2 hydrochloride

Solubility for JMS 17-2 hydrochloride

Dilution Calculator

Reconstitution Calculator

References for JMS 17-2 hydrochloride

Product Documents for JMS 17-2 hydrochloride

COA

Certificate of Analysis

SDS

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