JNJ 1013

Name: JNJ 1013
Brand: Tocris Bioscience
SKU: 8029

Tocris Bioscience, part of Bio-Techne | Catalog # 8029

COA / SDS

Interleukin 1 Receptor Associated Kinase 1 (IRAK1) Degrader (PROTAC®)

Key Product Details

Description:	Interleukin 1 Receptor Associated Kinase 1 (IRAK1) Degrader (PROTAC^®)
Chemical Name:	N-(4-(4-(2-(((S)-1-((2S,4R)-4-Hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)piperidin-1-yl)-2-methoxyphenyl)-6-(1H-pyrazol-5-yl)picolinamide
Purity:	≥98% (HPLC)
Molecular Weight:	878.06

View Full Technical Details for JNJ 1013

Technical Data
Citations

Biological Activity for JNJ 1013

JNJ 1013 is a potent interleukin 1 receptor associated kinase 1 (IRAK1) Degrader (PROTAC^®; DC₅₀ = 3 nM; D_max= 96%). In ABC DLBCL cell lines with MyD88 L265P mutation, JNJ 1013 potently inhibits IRAK1 downstream signaling pathways, induces apoptosis, and shows strong anti-proliferative effects.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for JNJ 1013

M. Wt	878.06
Formula	C₄₆H₅₅N₉O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2597343-08-1
PubChem ID	162660665
InChi Key	MHRNVFQJUUXQIG-VIFUUBRESA-N
Smiles	COC(C=C1N(CC2)CCC2OCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)=O)=O)=C(C=C1)NC(C6=CC=CC(C7=NNC=C7)=N6)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 1013

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	87.81	100

Preparing Stock Solutions for JNJ 1013

The following data is based on the product molecular weight 878.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.14 mL	5.69 mL	11.39 mL
5 mM	0.23 mL	1.14 mL	2.28 mL
10 mM	0.11 mL	0.57 mL	1.14 mL
50 mM	0.02 mL	0.11 mL	0.23 mL

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References for JNJ 1013

References are publications that support the biological activity of the product.

Fu Discovery of highly potent and selective IRAK1 Degraders to probe scaffolding functions of IRAK1 in ABC DLBCL. J.Med.Chem. 2021 PMID: 34279092