JNJ 10198409

Name: JNJ 10198409
Brand: Tocris Bioscience
SKU: 6976

Tocris Bioscience, part of Bio-Techne | Catalog # 6976

Citations (39)

COA / SDS

Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

Key Product Details

Description:	Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
Chemical Name:	N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine
Purity:	≥98% (HPLC)
Molecular Weight:	325.34

View Full Technical Details for JNJ 10198409

Technical Data
Citations

Biological Activity for JNJ 10198409

JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC₅₀ values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC₅₀ values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in transdifferentiation of human fibroblasts into functional cardiomyocytes, within 9C cocktail.

For more information about how JNJ 10198409 may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Compound Libraries for JNJ 10198409

JNJ 10198409 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 10198409

M. Wt	325.34
Formula	C₁₈H₁₆FN₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	627518-40-5
PubChem ID	9797370
InChi Key	ZDNURMVOKAERHZ-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=C2C(CC3=C2NN=C3NC2=CC(F)=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 10198409

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	6.51	20
	ethanol	32.53	100

Preparing Stock Solutions for JNJ 10198409

The following data is based on the product molecular weight 325.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.07 mL	15.37 mL	30.74 mL
5 mM	0.61 mL	3.07 mL	6.15 mL
10 mM	0.31 mL	1.54 mL	3.07 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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References for JNJ 10198409

References are publications that support the biological activity of the product.

Cao Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 PMID: 27127239
Ho (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J.Med.Chem. 2005 PMID: 16366598