JNJ 17203212

Name: JNJ 17203212
Brand: Tocris Bioscience
SKU: 3361

Tocris Bioscience, part of Bio-Techne | Catalog # 3361

Citations (11)

COA / SDS

Reversible, competitive and potent TRPV1 antagonist

Key Product Details

Description:	Reversible, competitive and potent TRPV1 antagonist
Chemical Name:	4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	419.32

View Full Technical Details for JNJ 17203212

Technical Data
Citations

Biological Activity for JNJ 17203212

JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist (pK_i values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H⁺-induced channel activation (pIC₅₀ values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo.

Compound Libraries for JNJ 17203212

JNJ 17203212 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 17203212

M. Wt	419.32
Formula	C₁₇H₁₅F₆N₅O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	821768-06-3
PubChem ID	11339118
InChi Key	JFRYYGVYCWYIDQ-UHFFFAOYSA-N
Smiles	O=C(NC3=NC=C(C(F)(F)F)C=C3)N(CC2)CCN2C1=C(C(F)(F)F)C=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 17203212

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.93	100
	ethanol	41.93	100

Preparing Stock Solutions for JNJ 17203212

The following data is based on the product molecular weight 419.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.85 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for JNJ 17203212

References are publications that support the biological activity of the product.

Ghilardi Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J.Neurosci. 2005 PMID: 15788769
Bhattacharya Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs. J.Pharmacol.Exp.Ther. 2007 PMID: 17690251
Swanson Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. J.Med.Chem. 2005 PMID: 15771431