JNJ 28871063 hydrochloride

Name: JNJ 28871063 hydrochloride
Brand: Tocris Bioscience
SKU: 3352

Tocris Bioscience, part of Bio-Techne | Catalog # 3352

Citations (1)

COA / SDS

Potent ErbB receptor family inhibitor

Key Product Details

Chemical Name:	5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride
Purity:	≥97%

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Technical Data
Citations

Biological Activity for JNJ 28871063 hydrochloride

JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor (IC₅₀ values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC₅₀ = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.

Technical Data for JNJ 28871063 hydrochloride

Formula	C₂₄H₂₇ClN₆O₃.HCl
Storage	Desiccate at +4°C
Purity	≥97%
CAS Number	944342-90-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 28871063 hydrochloride

Solubility

Soluble Soluble to 50 mM in DMSO

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References for JNJ 28871063 hydrochloride

References are publications that support the biological activity of the product.

Contessa and Hamstra Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol., 2008;73:271 PMID: 17981994
Emanuel et al. Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol., 2008;73:338 PMID: 17975007

JNJ 28871063 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3352

Key Product Details

Biological Activity for JNJ 28871063 hydrochloride

Technical Data for JNJ 28871063 hydrochloride

Solubility for JNJ 28871063 hydrochloride

Dilution Calculator

Reconstitution Calculator

References for JNJ 28871063 hydrochloride

Product Documents for JNJ 28871063 hydrochloride

COA

Certificate of Analysis

SDS

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