JP 1302 dihydrochloride

Name: JP 1302 dihydrochloride
Brand: Tocris Bioscience
SKU: 2666

Tocris Bioscience, part of Bio-Techne | Catalog # 2666

Citations (2)

COA / SDS

Potent and selective α2C antagonist

Key Product Details

Description:	Potent and selective α_2C antagonist
Chemical Name:	N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	441.4

View Full Technical Details for JP 1302 dihydrochloride

Technical Data
Citations

Biological Activity for JP 1302 dihydrochloride

JP 1302 dihydrochloride is an α_2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α₂-adrenoceptor subtypes (K_i values are 28, 1470, 1700 and 3150 nM for human α_2C, α_2B, α_2D and α_2A subtypes respectively). Potently antagonizes adrenalin-stimulated ³⁵GTPγS binding in vitro (K_B = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.

Technical Data for JP 1302 dihydrochloride

M. Wt	441.4
Formula	C₂₄H₂₄N₄.2HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1259314-65-2
PubChem ID	49855035
InChi Key	VVZOADYFJAJZGL-UHFFFAOYSA-N
Smiles	CN(CC5)CCN5C(C=C4)=CC=C4NC2=C3C(C=CC=C3)=NC1=CC=CC=C12.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JP 1302 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	44.14	100

Preparing Stock Solutions for JP 1302 dihydrochloride

The following data is based on the product molecular weight 441.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.33 mL	22.66 mL
5 mM	0.45 mL	2.27 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for JP 1302 dihydrochloride

References are publications that support the biological activity of the product.

Sallinen Pharmacological characterization and CNS effects of a novel highly selective α_2C-adrenoceptor antagonist JP-1302. Br.J.Pharmacol. 2007 PMID: 17220913
Tricklebank JP-1302: a new tool to shed light on the roles of α_2C-adrenoceptors in brain. Br.J.Pharmacol. 2007 PMID: 17220912