JQ dS-4

Name: JQ dS-4
Brand: Tocris Bioscience
SKU: 8152

Tocris Bioscience, part of Bio-Techne | Catalog # 8152

COA / SDS

BRG1/SMARCA4 Degrader (PROTAC®)

Key Product Details

Description:	BRG1/SMARCA4 Degrader (PROTAC^®)
Chemical Name:	3-((4-(3-(2-Chloropyridin-4-yl)ureido)pyridin-2-yl)ethynyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)benzamide
Purity:	≥95% (HPLC)
Molecular Weight:	719.16

View Full Technical Details for JQ dS-4

Technical Data
Citations

Biological Activity for JQ dS-4

JQ dS-4 is a Brahma-related gene 1 (BRG1)/BRM/SMARCA4 Degrader (PROTAC^®; IC₅₀ range = 9 - 390 nM in glioma models and cell lines). Comprises a BRG1 inhibitor joined by a linker to a cereblon (CRBN) E3 ligase ligand. Completely degrades BRG1 after 48 and 72 hours in HSJD-DIPG007 and SU-DIPGXIIIP cells and reduces viability of a variety of cancer cell lines including H3K27M glioma, prostate, thyroid and salivary gland.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for JQ dS-4

M. Wt	719.16
Formula	C₃₇H₃₁ClN₈O₆
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2688882-69-9
PubChem ID	156829976
InChi Key	IIYWQMYQROKRFZ-UHFFFAOYSA-N
Smiles	O=C(NC1=CC(C#CC2=CC=CC(C(NCCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)=C2)=NC=C1)NC6=CC(Cl)=NC=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JQ dS-4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	71.92	100

Preparing Stock Solutions for JQ dS-4

The following data is based on the product molecular weight 719.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.39 mL	6.95 mL	13.91 mL
5 mM	0.28 mL	1.39 mL	2.78 mL
10 mM	0.14 mL	0.70 mL	1.39 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for JQ dS-4

References are publications that support the biological activity of the product.

Panditharatna BAF complex maintains glioma stem cells in pediatric H3K27M glioma. Cancer Discov. 2022 PMID: 36305736