JT010

Name: JT010
Brand: Tocris Bioscience
SKU: 6269
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6269

(1)

Citations (7)

COA / SDS

Potent and selective TRPA1 channel activator

Key Product Details

Description:	Potent and selective TRPA1 channel activator
Chemical Name:	2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	354.85

View Full Technical Details for JT010

Technical Data
Citations / Reviews (1)

Biological Activity for JT010

JT010 is a potent and selective TRPA1 channel activator (EC₅₀ = 0.65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC₅₀ values are >1 μM).

Technical Data for JT010

M. Wt	354.85
Formula	C₁₆H₁₉ClN₂O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	917562-33-5
PubChem ID	18524489
InChi Key	KZMAWJRXKGLWGS-UHFFFAOYSA-N
Smiles	O=C(N(CCCOC)C1=NC(C2=CC=C(OC)C=C2)=CS1)CCl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JT010

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.48	100
	ethanol	17.74	50

Preparing Stock Solutions for JT010

The following data is based on the product molecular weight 354.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.09 mL	28.18 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for JT010

References are publications that support the biological activity of the product.

Takaya A potent and site-selective agonist of TRPA1. J.Am.Chem.Soc. 2015 PMID: 26630251