JTE 607 dihydrochloride

Name: JTE 607 dihydrochloride
Brand: Tocris Bioscience
SKU: 5185

Tocris Bioscience, part of Bio-Techne | Catalog # 5185

Citations (3)

COA / SDS

Active metabolite binds CPSF3; Pro-drug

Key Product Details

Chemical Name:	N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Purity:	≥98%

View Full Technical Details for JTE 607 dihydrochloride

Technical Data
Citations

Biological Activity for JTE 607 dihydrochloride

JTE 607 dihydrochloride is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3; K_d = 370 nM at human CPSF3). Treatment of A-673 cells with JTE 607 results in inhibition of mRNA cleavage and accumulation of nuclear R-loops. JTE 607 induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model. JTE 607 inhibits cytokine release and inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC₅₀ values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. In a rat model of lung injury, JTE 607 reduces proinflammatory cytokine-release and attenuates lung permeability.

Technical Data for JTE 607 dihydrochloride

Formula	C₂₅H₃₁Cl₂N₃O₅.2HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	188791-09-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JTE 607 dihydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for JTE 607 dihydrochloride

References are publications that support the biological activity of the product.

Tajima et al. JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Cancer Sci., 2010;101:774 PMID: 20028380
Kakutani et al. JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm.Res., 1999;48:461 PMID: 10493164
Jian JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats. Eur.J.Pharmacol., 2004;488:231 PMID: 15044056
Ross et al. CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma. Nat.Chem.Biol., 2020;16:50 PMID: 31819276

JTE 607 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5185

Key Product Details

Biological Activity for JTE 607 dihydrochloride

Technical Data for JTE 607 dihydrochloride

Solubility for JTE 607 dihydrochloride

Dilution Calculator

Reconstitution Calculator

References for JTE 607 dihydrochloride

Product Documents for JTE 607 dihydrochloride

COA

Certificate of Analysis

SDS

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