JTV 519 fumarate

Name: JTV 519 fumarate
Brand: Tocris Bioscience
SKU: 4564

Tocris Bioscience, part of Bio-Techne | Catalog # 4564

Citations (1)

COA / SDS

Ryanodine receptor (RyR) inhibitor

Key Product Details

Chemical Name:	1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
Purity:	≥98%

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Technical Data
Citations

Biological Activity for JTV 519 fumarate

JTV 519 fumarate is a ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.

Technical Data for JTV 519 fumarate

Formula	C₂₅H₃₂N₂O₂S.C₄H₄O₄
Storage	Store at +4°C
Purity	≥98%
CAS Number	1883549-36-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JTV 519 fumarate

Solubility

Soluble Soluble to 100 mM in DMSO

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References for JTV 519 fumarate

References are publications that support the biological activity of the product.

Hunt et al. K201 (JTV519) suppresses spontaneous Ca²⁺ release and [³H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J., 2007;404:431 PMID: 17313373
Chen et al. Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol., 2008;153:915 PMID: 17994112
Ye et al. Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol., 2012;81:53 PMID: 21989257

JTV 519 fumarate

Tocris Bioscience, part of Bio-Techne | Catalog # 4564

Key Product Details

Biological Activity for JTV 519 fumarate

Technical Data for JTV 519 fumarate

Solubility for JTV 519 fumarate

Dilution Calculator

Reconstitution Calculator

References for JTV 519 fumarate

Product Documents for JTV 519 fumarate

COA

Certificate of Analysis

SDS

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