JZP 430

Name: JZP 430
Brand: Tocris Bioscience
SKU: 5844

Tocris Bioscience, part of Bio-Techne | Catalog # 5844

COA / SDS

Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

Key Product Details

Description:	Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Chemical Name:	4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl N-cyclooctyl-N-methylcarbamate
Purity:	≥98% (HPLC)
Molecular Weight:	354.47

View Full Technical Details for JZP 430

Technical Data
Citations

Biological Activity for JZP 430

JZP 430 is a potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC₅₀ = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

Compound Libraries for JZP 430

JZP 430 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JZP 430

M. Wt	354.47
Formula	C₁₆H₂₆N₄O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1672691-74-5
PubChem ID	121513897
InChi Key	WKSHMJCYWFOADB-UHFFFAOYSA-N
Smiles	O=C(N(C)C1CCCCCCC1)OC2=NSN=C2N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JZP 430

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	17.72	50
	ethanol	7.09	20

Preparing Stock Solutions for JZP 430

The following data is based on the product molecular weight 354.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.64 mL	28.21 mL	56.42 mL
2.5 mM	1.13 mL	5.64 mL	11.28 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
25 mM	0.11 mL	0.56 mL	1.13 mL

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Reconstitution Calculator

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References for JZP 430

References are publications that support the biological activity of the product.

Patel Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 2015 PMID: 25504894