K 02288

Name: K 02288
Brand: Tocris Bioscience
SKU: 4986

Tocris Bioscience, part of Bio-Techne | Catalog # 4986

Citations (9)

COA / SDS

Type 1 BMP receptor inhibitor

Key Product Details

Chemical Name:	3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Purity:	≥99%

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Technical Data
Citations

Biological Activity for K 02288

K 02288 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC₅₀ = 100 nM) and induces dorsalization of zebrafish embryos.

Technical Data for K 02288

Formula	C₂₀H₂₀N₂O₄
Storage	Store at -20°C
Purity	≥99%
CAS Number	1431985-92-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for K 02288

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming

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References for K 02288

References are publications that support the biological activity of the product.

Mohedas et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol., 2013;8:1291 PMID: 23547776
Sanvitale et al. A new class of small molecule inhibitor of BMP signaling. PLoS ONE, 2013;8:62721 PMID: 23646137

K 02288

Tocris Bioscience, part of Bio-Techne | Catalog # 4986

Key Product Details

Biological Activity for K 02288

Technical Data for K 02288

Solubility for K 02288

Dilution Calculator

Reconstitution Calculator

References for K 02288

Product Documents for K 02288

COA

Certificate of Analysis

SDS

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