K 02288

Name: K 02288
Brand: Tocris Bioscience
SKU: 4986

Tocris Bioscience, part of Bio-Techne | Catalog # 4986

Citations (9)

COA / SDS

Type 1 BMP receptor inhibitor

Key Product Details

Description:	Type 1 BMP receptor inhibitor
Alternative Names:	K 02288a
Chemical Name:	3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Purity:	≥99% (HPLC)
Molecular Weight:	352.38

View Full Technical Details for K 02288

Technical Data
Citations

Biological Activity for K 02288

K 02288 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC₅₀ = 100 nM) and induces dorsalization of zebrafish embryos.

Compound Libraries for K 02288

K 02288 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for K 02288

M. Wt	352.38
Formula	C₂₀H₂₀N₂O₄
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1431985-92-0
PubChem ID	46173038
InChi Key	CJLMANFTWLNAKC-UHFFFAOYSA-N
Smiles	NC1=NC=C(C3=CC=CC(O)=C3)C=C1C2=CC(OC)=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for K 02288

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.24	100
	ethanol	3.52	10 with gentle warming

Preparing Stock Solutions for K 02288

The following data is based on the product molecular weight 352.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for K 02288

References are publications that support the biological activity of the product.

Mohedas Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 2013 PMID: 23547776
Sanvitale A new class of small molecule inhibitor of BMP signaling. PLoS ONE 2013 PMID: 23646137