KF 38789

Name: KF 38789
Brand: Tocris Bioscience
SKU: 2748
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2748

(1)

Citations (13)

COA / SDS

Selective inhibitor of P-selectin-mediated cell adhesion

Key Product Details

Description:	Selective inhibitor of P-selectin-mediated cell adhesion
Chemical Name:	3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
Purity:	≥97% (HPLC)
Molecular Weight:	375.44

View Full Technical Details for KF 38789

Technical Data
Citations / Reviews (1)

Biological Activity for KF 38789

KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion (IC₅₀ = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. KF 38789 blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.

Compound Libraries for KF 38789

KF 38789 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for KF 38789

M. Wt	375.44
Formula	C₁₉H₂₁NO₅S
Storage	Desiccate at +4°C
Purity	≥97% (HPLC)
CAS Number	257292-29-8
PubChem ID	5373277
InChi Key	FJDFKOSFDPIMBV-NBVRZTHBSA-N
Smiles	COC1=CC=C(C2CC(=NCCS2)C2=C(O)C=C(C)OC2=O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KF 38789

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.54	100

Preparing Stock Solutions for KF 38789

The following data is based on the product molecular weight 375.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.32 mL	26.64 mL
5 mM	0.53 mL	2.66 mL	5.33 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for KF 38789

References are publications that support the biological activity of the product.

Ohta Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779. Inflamm.Res. 2001 PMID: 11766994
Kaila Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J.Med.Chem. 2007 PMID: 17201408
Haggerty Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis. Chem.Biol. 2000 PMID: 10780927