KG 5

Tocris Bioscience, part of Bio-Techne | Catalog # 5260

COA / SDS

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Key Product Details

Chemical Name:	2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1_H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine
Purity:	≥98%

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Technical Data
Citations

Biological Activity for KG 5

KG 5 is a PDGFRβ and B-Raf allosteric inhibitor. Also inhibits c-Raf, FLT3 and KIT. Disrupts blood vessel formation in zebrafish embryos and inhibits angiogenesis in a mouse angiogenesis model. Inhibits growth of renal and pancreatic tumors in mice. Also arrests cells in prometaphase. Orally available.

Technical Data for KG 5

Formula	C₂₀H₁₆F₃N₇OS
Storage	Store at -20°C
Purity	≥98%
CAS Number	877874-85-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KG 5

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for KG 5

References are publications that support the biological activity of the product.

Murphy et al. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc.Natl.Acad.Sci.U.S.A., 2010;107:4299 PMID: 20154271
Mielgo et al. A MEK-independent role for CRAF in mitosis and tumor progression. Nat.Med., 2011;17 PMID: 22081024

KG 5

Tocris Bioscience, part of Bio-Techne | Catalog # 5260

Key Product Details

Biological Activity for KG 5

Technical Data for KG 5

Solubility for KG 5

Dilution Calculator

Reconstitution Calculator

References for KG 5

Product Documents for KG 5

COA

Certificate of Analysis

SDS

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