Kinesore

Name: Kinesore
Brand: Tocris Bioscience
SKU: 6664

Tocris Bioscience, part of Bio-Techne | Catalog # 6664

Citations (4)

COA / SDS

Kinesin-1 modulator; cell permeable

Key Product Details

Description:	Kinesin-1 modulator; cell permeable
Chemical Name:	3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	536.17

View Full Technical Details for Kinesore

Technical Data
Citations

Biological Activity for Kinesore

Kinesore is a kinesin-1 modulator. Inhibits SKIP-KLC2 interaction, but promotes kinesin-1 function in controlling the organization of the microtubule network. Induces remodeling of the microtubule network and the formation of extensive microtubule-rich projections. Cell permeable.

Technical Data for Kinesore

M. Wt	536.17
Formula	C₂₀H₁₆Br₂N₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	363571-83-9
PubChem ID	5507411
InChi Key	DUGCMEGLYHBMAR-RMORIDSASA-N
Smiles	CC1=CC(/C=N/NC(C2=CC(Br)=C(C(Br)=C2)O)=O)=C(N1C3=CC([N+]([O-])=O)=CC=C3)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Kinesore

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.62	100

Preparing Stock Solutions for Kinesore

The following data is based on the product molecular weight 536.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.33 mL	18.65 mL
5 mM	0.37 mL	1.87 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for Kinesore

References are publications that support the biological activity of the product.

Randall A small-molecule activator of kinesin-1 drives remodeling of the microtubule network. Proc.Natl.Acad.Sci.USA 2017 PMID: 29229862