KML 29

Name: KML 29
Brand: Tocris Bioscience
SKU: 4872

Tocris Bioscience, part of Bio-Techne | Catalog # 4872

Citations (7)

COA / SDS

Highly potent and selective MAGL inhibitor

Key Product Details

Description:	Highly potent and selective MAGL inhibitor
Chemical Name:	4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	549.42

View Full Technical Details for KML 29

Technical Data
Citations

Biological Activity for KML 29

KML 29 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC₅₀ values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC₅₀ > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC₅₀ = 2.5 nM and >50 μM for 2-AG and AEA respectively).

Licensing Information

Sold under license from The Scripps Research Institute

Compound Libraries for KML 29

KML 29 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for KML 29

M. Wt	549.42
Formula	C₂₄H₂₁F₆NO₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1380424-42-9
PubChem ID	71656212
InChi Key	SXHQLPHDBLTFPM-UHFFFAOYSA-N
Smiles	O=C(OC(C(F)(F)F)C(F)(F)F)N(CC5)CCC5C(C2=CC=C(OCO3)C3=C2)(O)C1=CC(OCO4)=C4C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KML 29

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.94	100

Preparing Stock Solutions for KML 29

The following data is based on the product molecular weight 549.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.82 mL	9.10 mL	18.20 mL
5 mM	0.36 mL	1.82 mL	3.64 mL
10 mM	0.18 mL	0.91 mL	1.82 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for KML 29

References are publications that support the biological activity of the product.

Chang Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 2012 PMID: 22542104
Ueda Discrimination between two endocannabinoids. Chem.Biol. 2012 PMID: 22633404