KRIBB11

Name: KRIBB11
Brand: Tocris Bioscience
SKU: 5480

Tocris Bioscience, part of Bio-Techne | Catalog # 5480

Citations (4)

COA / SDS

HSF1 inhibitor

Key Product Details

Description:	HSF1 inhibitor
Chemical Name:	N²-1H-Indazol-5-yl-N⁶-methyl-3-nitro-2,6-pyridinediamine
Purity:	≥99% (HPLC)
Molecular Weight:	284.27

View Full Technical Details for KRIBB11

Technical Data
Citations

Biological Activity for KRIBB11

KRIBB11 is a heat shock factor (HSF) inhibitor (IC₅₀ = 1.2 μM). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo.

Technical Data for KRIBB11

M. Wt	284.27
Formula	C₁₃H₁₂N₆O₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	342639-96-7
PubChem ID	69894253
InChi Key	NDJJEQIMIJJCLL-UHFFFAOYSA-N
Smiles	CNC1=NC(NC2=CC=C(NN=C3)C3=C2)=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KRIBB11

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.43	100

Preparing Stock Solutions for KRIBB11

The following data is based on the product molecular weight 284.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.59 mL	35.18 mL
5 mM	0.70 mL	3.52 mL	7.04 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for KRIBB11

References are publications that support the biological activity of the product.

Samarasinghe Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem. Pharmacol. 2014 PMID: 24291777
Yoon KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J.Biol.Chem. 2011 PMID: 21078672