KT 182

Name: KT 182
Brand: Tocris Bioscience
SKU: 6738

Tocris Bioscience, part of Bio-Techne | Catalog # 6738

COA / SDS

Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

Key Product Details

Description:	Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Chemical Name:	[4-[3'-(Hydroxymethyl)[1,1'-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone
Purity:	≥98% (HPLC)
Molecular Weight:	438.53

View Full Technical Details for KT 182

Technical Data
Citations

Biological Activity for KT 182

KT 182 is a potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC₅₀ = 1.7 nM). KT 182 exhibits selectively for ABHD6 over other brain and liver serine hydrolases, but does exhibit some activity at carboxylesterase-1. KT 182 inhibits ABHD6 activity in the brain and liver in mice following intraperitoneal administration.

Technical Data for KT 182

M. Wt	438.53
Formula	C₂₇H₂₆N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1402612-62-7
PubChem ID	53364491
InChi Key	GICNKPZHUCVFNM-UHFFFAOYSA-N
Smiles	OCC1=CC=CC(C2=CC=C(C3=CN(C(N4CCCCC4C5=CC=CC=C5)=O)N=N3)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KT 182

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.85	100

Preparing Stock Solutions for KT 182

The following data is based on the product molecular weight 438.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.40 mL	22.80 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for KT 182

References are publications that support the biological activity of the product.

Hsu Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6) J.Med.Chem. 2013 PMID: 24152295