KU 0060648

Name: KU 0060648
Brand: Tocris Bioscience
SKU: 4840

Tocris Bioscience, part of Bio-Techne | Catalog # 4840

Citations (1)

COA / SDS

Dual DNA-PK and PI 3-K inhibitor

Key Product Details

Chemical Name:	4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide
Purity:	≥97%

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Technical Data
Citations

Biological Activity for KU 0060648

KU 0060648 is a dual PI 3-K and DNA-PK inhibitor (IC₅₀ values are <0.1, 0.5, 4 and 19 nM for PI 3-Kδ, PI 3-Kβ, PI 3-Kα and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ~2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%; maximum effect seen at 250 nM.

Technical Data for KU 0060648

Formula	C₃₃H₃₄N₄O₄S
Storage	Store at -20°C
Purity	≥97%
CAS Number	881375-00-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KU 0060648

Solubility

Soluble Soluble to 100 mM in 2eq.HCl

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References for KU 0060648

References are publications that support the biological activity of the product.

Munck et al. Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. Mol.Cancer Ther., 2012;11:1789 PMID: 22576130
Dumont et al. Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches. Expert Opin.Ther.Patents, 2009;19:775 PMID: 19456277
Robert et al. Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med., 2015;7:93 PMID: 26307031

KU 0060648

Tocris Bioscience, part of Bio-Techne | Catalog # 4840

Key Product Details

Biological Activity for KU 0060648

Technical Data for KU 0060648

Solubility for KU 0060648

Dilution Calculator

Reconstitution Calculator

References for KU 0060648

Product Documents for KU 0060648

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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