L-365,260

Name: L-365,260
Brand: Tocris Bioscience
SKU: 2767

Tocris Bioscience, part of Bio-Techne | Catalog # 2767

Citations (9)

COA / SDS

Selective CCK2 antagonist

Key Product Details

Description:	Selective CCK₂ antagonist
Chemical Name:	N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea
Purity:	≥99% (HPLC)
Molecular Weight:	398.46

View Full Technical Details for L-365,260

Technical Data
Citations

Biological Activity for L-365,260

L-365,260 is a selective cholecystokinin receptor 2 (CCK₂) antagonist (IC₅₀ values are 2 and 280 nM at CCK₂ and CCK₁ receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.

Technical Data for L-365,260

M. Wt	398.46
Formula	C₂₄H₂₂N₄O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	118101-09-0
PubChem ID	5311201
InChi Key	KDFQABSFVYLGPM-QFIPXVFZSA-N
Smiles	O=C1[C@H](NC(NC4=CC=CC(C)=C4)=O)N=C(C3=CC=CC=C3)C2=C(C=CC=C2)N1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-365,260

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.85	100
	ethanol	39.85	100

Preparing Stock Solutions for L-365,260

The following data is based on the product molecular weight 398.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.55 mL	25.10 mL
5 mM	0.50 mL	2.51 mL	5.02 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for L-365,260

References are publications that support the biological activity of the product.

Lotti and Chang A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. Eur.J.Pharmacol. 1989 PMID: 2721567
Chung Cholecystokinin action on layer 6b neurons in somatosensory cortex. Brain Res. 2009 PMID: 19497313
Kees Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260. J.Med.Chem. 1989 PMID: 2909725