L 760735

Name: L 760735
Brand: Tocris Bioscience
SKU: 4013

Tocris Bioscience, part of Bio-Techne | Catalog # 4013

Citations (6)

COA / SDS

High affinity NK1 antagonist

Key Product Details

Description:	High affinity NK₁ antagonist
Chemical Name:	5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	611.98

View Full Technical Details for L 760735

Technical Data
Citations

Biological Activity for L 760735

L 760735 is a high affinity NK₁ receptor antagonist (IC₅₀ = 0.19 nM at human NK₁ receptors). Selective (>300-fold) over h-NK₂ and h-NK₃ receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.

Compound Libraries for L 760735

L 760735 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L 760735

M. Wt	611.98
Formula	C₂₆H₂₈F₇N₅O₂.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	188923-01-5
PubChem ID	9809076
InChi Key	VZBKOBSSEVXFNF-QIRDZIKRSA-N
Smiles	FC(C=C3)=CC=[C@@]3[C@@H]1N(CC4=C(CN(C)C)NN=N4)CCO[C@@H]1O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L 760735

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	18.36	30
	DMSO	30.6	50

Preparing Stock Solutions for L 760735

The following data is based on the product molecular weight 611.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.27 mL	16.34 mL	32.68 mL
2.5 mM	0.65 mL	3.27 mL	6.54 mL
5 mM	0.33 mL	1.63 mL	3.27 mL
25 mM	0.07 mL	0.33 mL	0.65 mL

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References for L 760735

References are publications that support the biological activity of the product.

Duffy Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther 2002 PMID: 11961054
Harrison An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. J.Med.Chem. 2001 PMID: 11708932