L-803,087 trifluoroacetate

Name: L-803,087 trifluoroacetate
Brand: Tocris Bioscience
SKU: 1979

Tocris Bioscience, part of Bio-Techne | Catalog # 1979

COA / SDS

Potent and selective sst4 agonist

Discontinued Product

1979 has been discontinued. View all Somatostatin Receptor Agonists products.

Key Product Details

Description:	Potent and selective sst₄ agonist
Chemical Name:	N²-[4-(5,7-Difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-L-arginine methyl ester trifluoroacetate
Purity:	≥97% (HPLC)
Molecular Weight:	599.56

View Full Technical Details for L-803,087 trifluoroacetate

Technical Data
Citations

Biological Activity for L-803,087 trifluoroacetate

L-803,087 trifluoroacetate is a potent and selective somatostatin sst₄ receptor agonist. K_i values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst₄, sst₁, sst₂, sst₃ and sst₅ receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo.

Technical Data for L-803,087 trifluoroacetate

M. Wt	599.56
Formula	C₂₅H₂₉F₂N₅O₃.CF₃CO₂H
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1786412-46-1
PubChem ID	45073436
InChi Key	IIRYZHRNVKQVGQ-BDQAORGHSA-N
Smiles	FC(F)(F)C(O)=O.NC(NCCC[C@@H]([C@@](OC)=O)NC(CCCC1=C(C3=CC=CC=C3)NC2=C1C=C(F)C=C2F)=O)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for L-803,087 trifluoroacetate

References are publications that support the biological activity of the product.

Rohrer and Schaeffer Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris 2000 PMID: 11087999
Moneta Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur.J.Neurosci. 2002 PMID: 12372020
Rohrer Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 1998 PMID: 9784130

L-803,087 trifluoroacetate

Tocris Bioscience, part of Bio-Techne | Catalog # 1979

Key Product Details

Biological Activity for L-803,087 trifluoroacetate

Technical Data for L-803,087 trifluoroacetate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for L-803,087 trifluoroacetate

Product Documents for L-803,087 trifluoroacetate

COA

Certificate of Analysis

SDS

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