L-AP4

Tocris Bioscience, part of Bio-Techne | Catalog # 0103

(1)

Citations (332)

COA / SDS

Selective group III mGlu agonist

Key Product Details

Description:	Selective group III mGlu agonist
Chemical Name:	L-(+)-2-Amino-4-phosphonobutyric acid
Purity:	≥99% (HPLC)
Molecular Weight:	183.1

View Full Technical Details for L-AP4

Technical Data
Citations / Reviews (1)

Biological Activity for L-AP4

L-AP4 is a selective group III metabotropic glutamate receptor agonist that acts at mGlu4, mGlu8, mGlu6 and mGlu7 receptors (EC₅₀ values = 0.1-0.13 μM, 0.29 μM, 1.0-2.4 μM and 249-337 μM, respectively). L-AP4 is a synaptic depressant and inhibits excitatory post-synaptic currents. L-AP4 is also an agonist at the quisqualate-sensitized AP6 site in hippocampus.

DL Mixture and D-isomer also available.

Technical Data for L-AP4

M. Wt	183.1
Formula	C₄H₁₀NO₅P
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	23052-81-5
PubChem ID	179394
InChi Key	DDOQBQRIEWHWBT-VKHMYHEASA-N
Smiles	[H][C@@](CCP(O)(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-AP4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	0.92	5
	1eq. NaOH	18.31	100

Preparing Stock Solutions for L-AP4

The following data is based on the product molecular weight 183.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.46 mL	27.31 mL	54.61 mL
5 mM	1.09 mL	5.46 mL	10.92 mL
10 mM	0.55 mL	2.73 mL	5.46 mL
50 mM	0.11 mL	0.55 mL	1.09 mL

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Reconstitution Calculator

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References for L-AP4

References are publications that support the biological activity of the product.

Selvam Increased potency and selectivity for group III metabotropic glutamate receptor agonists binding at dual sites. J.Med.Chem. 2018 PMID: 29397723
Tones The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain. NeuroReport 1995 PMID: 8742431
Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024
Nakanishi Molecular diversity of glutamate receptors and implications for brain functions. Science 1992 PMID: 1329206
Bushell Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4. Neuropharmacology 1995 PMID: 7617150