L-Ascorbic acid

Name: L -Ascorbic acid
Brand: Tocris Bioscience
SKU: 4055

Tocris Bioscience, part of Bio-Techne | Catalog # 4055

(2)

Citations (35)

COA / SDS

Enhances the generation of iPSCs; increases reprogramming efficiency

Key Product Details

Chemical Name:	3-Oxo-L-gulofuranolactone
Purity:	≥99%
Molecular Weight:	176.12 kDa

View Full Technical Details for L-Ascorbic acid

Technical Data
Citations / Reviews (2)

Biological Activity for L-Ascorbic acid

L-Ascorbic acid is an inhibitor of Ca_v3.2 channels (IC₅₀ = 6.5 μM); displays no effect on Ca_v3.1 or Ca_v3.3 channels heterologously expressed in HEK 293 cells. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing reprogramming efficiency. Commonly used antifade reagent in live cell microscopy. Naturally occurring antioxidant.

L-Ascorbic acid synthesized to Ancillary Material Grade also available.

For more information about how L-Ascorbic acid may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Technical Data for L-Ascorbic acid

M. Wt	176.12 kDa
Formula	C₆H₈O₆
Storage	Store at RT
Purity	≥99%
CAS Number	50-81-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-Ascorbic acid

Solubility

Soluble Soluble to 500 mM in water

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References for L-Ascorbic acid

References are publications that support the biological activity of the product.

B Wang, JH Joo, R Mount, BJW Teubner, A Krenzer, AL Ward, VP Ichhaporia, EJ Adams, R Khoriaty, ST Peters, SM Pruett-Mil, SS Zakharenko, D Ginsburg, M Kundu The COPII cargo adapter SEC24C is essential for neuronal homeostasis J. Clin. Invest., 2018;0(0):. 2018 PMID: 29939162
Padayatty et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J.Am.Coll.Nutr., 2003;22:18 PMID: 12569111
Nelson et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J.Neurosci., 2007;27:12577 PMID: 18003836
Esteban et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 2010;6:71 PMID: 20036631
Cordes et al. Mechanisms and advancement of antifading agents for fluorescence microscopy and single-molecule spectroscopy. Phys.Chem.Chem.Phys., 2011;13:6699 PMID: 21311807