L-NIO dihydrochloride

Name: L-NIO dihydrochloride
Brand: Tocris Bioscience
SKU: 0546

Tocris Bioscience, part of Bio-Techne | Catalog # 0546

Citations (14)

COA / SDS

NOS inhibitor

Key Product Details

Description:	NOS inhibitor
Chemical Name:	N⁵-(1-Iminoethyl)-L-ornithine dihydrochloride
Molecular Weight:	246.13

View Full Technical Details for L-NIO dihydrochloride

Technical Data
Citations

Biological Activity for L-NIO dihydrochloride

L-NIO dihydrochloride is an Inhibitor of nitric oxide (NO) synthase. Inhibits iNOS, eNOS and nNOS. Active in vivo.

Technical Data for L-NIO dihydrochloride

M. Wt	246.13
Formula	C₇H₁₅N₃O₂.2HCl
Storage	Desiccate at -20°C
CAS Number	159190-44-0
PubChem ID	2733507
InChi Key	RYCMAAFECCXGHI-ILKKLZGPSA-N
Smiles	N[C@H](C(O)=O)CCCNC(C)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-NIO dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	24.61	100

Preparing Stock Solutions for L-NIO dihydrochloride

The following data is based on the product molecular weight 246.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.06 mL	20.31 mL	40.63 mL
5 mM	0.81 mL	4.06 mL	8.13 mL
10 mM	0.41 mL	2.03 mL	4.06 mL
50 mM	0.08 mL	0.41 mL	0.81 mL

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Reconstitution Calculator

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References for L-NIO dihydrochloride

References are publications that support the biological activity of the product.

Mulligan Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Br.J.Pharmacol. 1992 PMID: 1281719
Rees Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br.J.Pharmacol. 1990 PMID: 1706208
Moncada XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol.Rev. 1997 PMID: 9228663