L-Quisqualic acid

Name: L-Quisqualic acid
Brand: Tocris Bioscience
SKU: 0188

Tocris Bioscience, part of Bio-Techne | Catalog # 0188

Citations (31)

COA / SDS

AMPA agonist; also group I mGlu agonist

Key Product Details

Chemical Name:	(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
Purity:	≥99%
Molecular Weight:	189.13 kDa

View Full Technical Details for L-Quisqualic acid

Technical Data
Citations

Biological Activity for L-Quisqualic acid

L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. L-Quisqualic acid sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect).

Technical Data for L-Quisqualic acid

M. Wt	189.13 kDa
Formula	C₅H₇N₃O₅
Storage	Store at RT
Purity	≥99%
CAS Number	52809-07-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-Quisqualic acid

Solubility

Soluble Soluble to 100 mM in 1eq. NaOH and to 10 mM in water

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References for L-Quisqualic acid

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Ayoub MA, Angelicheva D, Vile D Deleterious GRM1 mutations in schizophrenia. PLoS ONE, 2012;7(3):e32849. 2012 PMID: 22448230
Littman et al. Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus. Neuropharmacology, 1995;34:829 PMID: 8532164
Schulte et al. Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res., 1994;649:203 PMID: 7953634
Porter et al. (S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor. Br.J.Pharmacol., 1992;106:509 PMID: 1324071