Lamotrigine

Name: Lamotrigine
Brand: Tocris Bioscience
SKU: 1611

Tocris Bioscience, part of Bio-Techne | Catalog # 1611

Citations (18)

COA / SDS

Inhibits glutamate release. Anticonvulsant

Key Product Details

Description:	Inhibits glutamate release. Anticonvulsant
Chemical Name:	6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Purity:	≥99% (HPLC)
Molecular Weight:	256.09

View Full Technical Details for Lamotrigine

Technical Data
Citations

Biological Activity for Lamotrigine

Lamotrigine is an anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na⁺, K⁺ and Ca²⁺ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na⁺ channels.

Water-soluble Salt also available.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for Lamotrigine

M. Wt	256.09
Formula	C₉H₇Cl₂N₅
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	84057-84-1
PubChem ID	3878
InChi Key	PYZRQGJRPPTADH-UHFFFAOYSA-N
Smiles	NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lamotrigine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.61	100

Preparing Stock Solutions for Lamotrigine

The following data is based on the product molecular weight 256.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.90 mL	19.52 mL	39.05 mL
5 mM	0.78 mL	3.90 mL	7.81 mL
10 mM	0.39 mL	1.95 mL	3.90 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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References for Lamotrigine

References are publications that support the biological activity of the product.

Zona and Avoli Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 1997 PMID: 9184596
Leach Neurochemical and behavioral aspects of lamotr. Epilepsia 1991 PMID: 1685439
Zheng The anticonvulsive drug lamotr. blocks neuronal α4β2 nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 2010 PMID: 20688974
Grunze Modulation of calcium and potassium currents by lamotr. Neuropsychobiology 1998 PMID: 9778600