Latrunculin A

Name: Latrunculin A
Brand: Tocris Bioscience
SKU: 3973

Tocris Bioscience, part of Bio-Techne | Catalog # 3973

Citations (87)

COA / SDS

Inhibitor of actin assembly and polymerization

Key Product Details

Description:	Inhibitor of actin assembly and polymerization
Chemical Name:	4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
Purity:	≥95% (HPLC)
Molecular Weight:	421.55

View Full Technical Details for Latrunculin A

Technical Data
Citations

Biological Activity for Latrunculin A

Latrunculin A is a reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.

This product is typically reconstituted in DMSO as a primary solvent.

Technical Data for Latrunculin A

M. Wt	421.55
Formula	C₂₂H₃₁NO₅S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	76343-93-6
PubChem ID	445420
InChi Key	DDVBPZROPPMBLW-IZGXTMSKSA-N
Smiles	C[C@@H](CC[C@]2([H])C[C@@](C[C@](O)([C@]3([H])CSC(N3)=O)O2)([H])O1)\C=C/C=C/CC/C(C)=C\C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Latrunculin A

References are publications that support the biological activity of the product.

Morton Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat.Cell Biol. 2000 PMID: 10854330
Blasberger On the chemistry of latrunculins A and B. Liebigs.Ann.Chem.
Yarmola Actin-latrunculin A structure and function. J.Biol.Chem. 2000 PMID: 10859320

Latrunculin A

Tocris Bioscience, part of Bio-Techne | Catalog # 3973

Key Product Details

Biological Activity for Latrunculin A

Technical Data for Latrunculin A

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Latrunculin A

Product Documents for Latrunculin A

COA

Certificate of Analysis

SDS

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