Latrunculin B

Name: Latrunculin B
Brand: Tocris Bioscience
SKU: 3974

Tocris Bioscience, part of Bio-Techne | Catalog # 3974

Citations (27)

COA / SDS

Inhibitor of actin polymerization

Key Product Details

Description:	Inhibitor of actin polymerization
Chemical Name:	(4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
Purity:	≥95% (HPLC)
Molecular Weight:	395.51

View Full Technical Details for Latrunculin B

Technical Data
Citations

Biological Activity for Latrunculin B

Latrunculin B is an inhibitor of actin polymerization. Interacts with G-actin in a 1:1 ratio to inhibit polymerization into F-actin in vitro (IC₅₀ values are ~60 and ~900 nM in absence and presence of calf serum, respectively). Marine toxin.

Technical Data for Latrunculin B

M. Wt	395.51
Formula	C₂₀H₂₉NO₅S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	76343-94-7
PubChem ID	3892
InChi Key	NSHPHXHGRHSMIK-UHFFFAOYSA-N
Smiles	O=C1/C=C(C)\CC/C=C\[C@@H](C)CC[C@@H]2C[C@H](C[C@](O)([C@@]3([H])NC(SC3)=O)O2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Latrunculin B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.78	50
	ethanol	19.78	50

Preparing Stock Solutions for Latrunculin B

The following data is based on the product molecular weight 395.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.06 mL	25.28 mL	50.57 mL
2.5 mM	1.01 mL	5.06 mL	10.11 mL
5 mM	0.51 mL	2.53 mL	5.06 mL
25 mM	0.10 mL	0.51 mL	1.01 mL

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References for Latrunculin B

References are publications that support the biological activity of the product.

Wakatsuki Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J.Cell.Sci. 2001 PMID: 11181185