LC 2 Epimer

Name: LC 2 Epimer
Brand: Tocris Bioscience
SKU: 7421

Tocris Bioscience, part of Bio-Techne | Catalog # 7421

COA / SDS

Negative control for LC 2 (Cat. No. 7420)

Key Product Details

Description:	Negative control for LC 2 (Cat. No. 7420)
Chemical Name:	(2S,4S)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	1132.8

View Full Technical Details for LC 2 Epimer

Technical Data
Citations

Biological Activity for LC 2 Epimer

Negative control for LC 2 (Cat. No. 7420).

Technical Data for LC 2 Epimer

M. Wt	1132.8
Formula	C₅₉H₇₁ClFN₁₁O₇S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2502156-12-7
InChi Key	ZCGQZLKPUVGCBQ-QDHBVFLESA-N
Smiles	CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@H](O)CN3C([C@@H](NC(CCOCCCN4CCC[C@H]4COC5=NC(N6CCN([C@@H](CC#N)C6)C(C(F)=C)=O)=C7CCN(CC7=N5)C8=CC=CC9=C8C(Cl)=CC=C9)=O)C(C)(C)C)=O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LC 2 Epimer

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	113.28	100

Preparing Stock Solutions for LC 2 Epimer

The following data is based on the product molecular weight 1132.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.88 mL	4.41 mL	8.83 mL
5 mM	0.18 mL	0.88 mL	1.77 mL
10 mM	0.09 mL	0.44 mL	0.88 mL
50 mM	0.02 mL	0.09 mL	0.18 mL

Molarity Calculator

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Reconstitution Calculator

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References for LC 2 Epimer

References are publications that support the biological activity of the product.

Bond Targeted degradation of oncogenic KRAS ^G12C by VHL-recruiting PROTACs. ACS Cent.Sci. 2020 PMID: 32875077
De Vita The missing link between (un)druggable and degradable KRAS. ACS Cent.Sci. 2020 PMID: 32875070