LDN 193188

Name: LDN 193188
Brand: Tocris Bioscience
SKU: 5631

Tocris Bioscience, part of Bio-Techne | Catalog # 5631

COA / SDS

Inhibitor of phosphatidylcholine transfer protein (PC-TP)

Key Product Details

Description:	Inhibitor of phosphatidylcholine transfer protein (PC-TP)
Chemical Name:	2,4-Dichloro-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]carbonyl]benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	494.35

View Full Technical Details for LDN 193188

Technical Data
Citations

Biological Activity for LDN 193188

LDN 193188 is an inhibitor of phosphatidylcholine transfer protein (PC-TP). Regulates hepatic glucose metabolism. Also promotes insulin-independent phosphorylation of key insulin signaling molecules.

Technical Data for LDN 193188

M. Wt	494.35
Formula	C₂₀H₁₇Cl₂N₅O₄S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1267610-30-9
PubChem ID	66958626
InChi Key	COTBDKMEUUNJTI-UHFFFAOYSA-N
Smiles	O=C(NC(NC1=CC=C(S(NC2=NC(C)=CC(C)=N2)(=O)=O)C=C1)=O)C3=C(Cl)C=C(Cl)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LDN 193188

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.44	100

Preparing Stock Solutions for LDN 193188

The following data is based on the product molecular weight 494.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.11 mL	20.23 mL
5 mM	0.40 mL	2.02 mL	4.05 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for LDN 193188

References are publications that support the biological activity of the product.

Wagle Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal.Biochem. 2008 PMID: 18762160
Shishova Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 2011 PMID: 21538437