LE 300

Name: LE 300
Brand: Tocris Bioscience
SKU: 1674

Tocris Bioscience, part of Bio-Techne | Catalog # 1674

Citations (14)

COA / SDS

Potent and selective D1 antagonist

Key Product Details

Description:	Potent and selective D₁ antagonist
Chemical Name:	6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f][3]benzazecine
Purity:	≥98% (HPLC)
Molecular Weight:	290.41

View Full Technical Details for LE 300

Technical Data
Citations

Biological Activity for LE 300

LE 300 is a potent and selective dopamine D₁ receptor antagonist (K_i values are 0.08 - 1.9 nM and 6 - 45 nM for D₁ and D₂ receptors respectively). Also displays moderate affinity for the 5-HT_2A receptor (K_i = 20 nM). Active in vivo.

Compound Libraries for LE 300

LE 300 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LE 300

M. Wt	290.41
Formula	C₂₀H₂₂N₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	274694-98-3
PubChem ID	4350931
InChi Key	YEWGIGCYIAMFMA-UHFFFAOYSA-N
Smiles	CN1CCC2=C(CC3=CC=CC=C3CC1)NC1=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LE 300

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	14.52	50
	DMSO	29.04	100

Preparing Stock Solutions for LE 300

The following data is based on the product molecular weight 290.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.44 mL	17.22 mL	34.43 mL
5 mM	0.69 mL	3.44 mL	6.89 mL
10 mM	0.34 mL	1.72 mL	3.44 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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References for LE 300

References are publications that support the biological activity of the product.

Kassack Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a novel type of a nanomolar DA receptor antagonist. Naunyn Schmiedebergs Arch.Pharmacol. 2002 PMID: 12444495
Witt 7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new heterocyclic system and a new lead compound for DA receptor antagonists. J.Med.Chem. 2000 PMID: 10821720
El-Subbagh DA/serotonin receptor ligands: Part IV [1]: Synthesis and pharmacology of novel 3-benzazecines and 3-benzazonines as potential 5-HT_2A and DA receptor ligands. Arch.Pharm. (Weinheim). 2002 PMID: 12447918