Levetiracetam

Name: Levetiracetam
Brand: Tocris Bioscience
SKU: 2839

Tocris Bioscience, part of Bio-Techne | Catalog # 2839

Citations (5)

COA / SDS

Binds SV2A; antiepileptic

Key Product Details

Description:	Binds SV2A; antiepileptic
Alternative Names:	Keppra,UCB L059
Chemical Name:	(2S)-(2-Oxopyrrolidin-1-yl)butyramide
Purity:	≥99% (HPLC)
Molecular Weight:	170.21

View Full Technical Details for Levetiracetam

Technical Data
Citations

Biological Activity for Levetiracetam

Levetiracetam is an antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na⁺-dependent Cl^-/HCO₃^- exchange. In a mouse model of Alzheimer's disease, Levetiracetam rescues levels of presynaptic vesicle fusion and neurotransmitter release, reduces Aβ42 and APP levels and decreases deposits of amyloid plaque; in vitro Levetiracetam inhibits Aβ-induced glutamate from astrocytes.

Compound Libraries for Levetiracetam

Levetiracetam is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Levetiracetam

M. Wt	170.21
Formula	C₈H₁₄N₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	102767-28-2
PubChem ID	5284583
InChi Key	HPHUVLMMVZITSG-LURJTMIESA-N
Smiles	O=C1N([C@@H](CC)C(N)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Levetiracetam

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	17.02	100
	DMSO	17.02	100

Preparing Stock Solutions for Levetiracetam

The following data is based on the product molecular weight 170.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.88 mL	29.38 mL	58.75 mL
5 mM	1.18 mL	5.88 mL	11.75 mL
10 mM	0.59 mL	2.94 mL	5.88 mL
50 mM	0.12 mL	0.59 mL	1.18 mL

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References for Levetiracetam

References are publications that support the biological activity of the product.

Rao and Savas Levetiracetam treatment normalizes levels of presynaptic endocytosis machinery and restores nonamyloidogenic APP processing in App knock-in mice J.Proteome Res. 2021 PMID: 34106705
Sanz-Blasco Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes. Neuroreport 2016 PMID: 27183239
Sanchez Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc.Natl.Acad.Sci. USA 2012 PMID: 22869752
Lynch The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug LeveT. Proct.Natl.Acad.Sci. USA 2004 PMID: 15210974
Ueda Effect of LeveT on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl₃ injection. Brain Res. 2007 PMID: 17408599
Smedt LeveT: the profile of a novel anticonvulsant drug - part I: preclinical data. CNS Drug Rev. 2007 PMID: 17461889