Linopirdine dihydrochloride

Name: Linopirdine dihydrochloride
Brand: Tocris Bioscience
SKU: 1999

Tocris Bioscience, part of Bio-Techne | Catalog # 1999

(1)

Citations (246)

COA / SDS

KV7 (KCNQ) channel blocker

Key Product Details

Chemical Name:	1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride
Purity:	≥99%
Molecular Weight:	464.39 kDa

View Full Technical Details for Linopirdine dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Linopirdine dihydrochloride

Linopirdine dihydrochloride is a blocker of K_V7 (KCNQ) voltage-gated potassium channels; blocks K_V7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC₅₀ = 4 - 7 μM) and K_V7.1 (KCNQ1) homomeric channels (IC₅₀ = 8.9 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Technical Data for Linopirdine dihydrochloride

M. Wt	464.39 kDa
Formula	C₂₆H₂₁N₃O.2HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	113168-57-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Linopirdine dihydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for Linopirdine dihydrochloride

References are publications that support the biological activity of the product.

Wang et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science, 1998;282:1890 PMID: 9836639
Zaczek et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther., 1998;285:724 PMID: 9580619
Schnee and Brown Selectivity of linopirdine (DuP 966), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J.Pharmacol.Exp.Ther., 1998;286:709 PMID: 9694925