LM22B 10

Name: LM22B 10
Brand: Tocris Bioscience
SKU: 6037

Tocris Bioscience, part of Bio-Techne | Catalog # 6037

Citations (6)

COA / SDS

TrkB and TrkC agonist; brain penetrant

Key Product Details

Description:	TrkB and TrkC agonist; brain penetrant
Chemical Name:	2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol
Purity:	≥98% (HPLC)
Molecular Weight:	485.02

View Full Technical Details for LM22B 10

Technical Data
Citations

Biological Activity for LM22B 10

LM22B 10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC₅₀ = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.

Compound Libraries for LM22B 10

LM22B 10 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LM22B 10

M. Wt	485.02
Formula	C₂₇H₃₃ClN₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	342777-54-2
PubChem ID	542158
InChi Key	QCXQLSGBOUUVNH-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LM22B 10

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	48.5	100
	ethanol	4.85	10

Preparing Stock Solutions for LM22B 10

The following data is based on the product molecular weight 485.02.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.31 mL	20.62 mL
5 mM	0.41 mL	2.06 mL	4.12 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for LM22B 10

References are publications that support the biological activity of the product.

Yang A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology 2016 PMID: 27334657