LNT 1

Name: LNT 1
Brand: Tocris Bioscience
SKU: 6510

Tocris Bioscience, part of Bio-Techne | Catalog # 6510

Citations (5)

COA / SDS

Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response

Key Product Details

Chemical Name:	1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Purity:	≥98%

View Full Technical Details for LNT 1

Technical Data
Citations

Biological Activity for LNT 1

LNT 1 is a potent flap endonuclease 1 (FEN1) inhibitor (IC₅₀ = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.

Technical Data for LNT 1

Formula	C₁₅H₁₂N₂O₅S
Storage	Store at -20°C
Purity	≥98%
CAS Number	824983-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LNT 1

Solubility

Soluble Soluble to 50 mM in DMSO

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for LNT 1

References are publications that support the biological activity of the product.

Ward TA, McHugh PJ, Durant ST. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS ONE. 2017-06-19 PMID: 28628639
Exell et al. Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio., 2016;12:815 PMID: 27526030

LNT 1

Tocris Bioscience, part of Bio-Techne | Catalog # 6510

Key Product Details

Biological Activity for LNT 1

Technical Data for LNT 1

Solubility for LNT 1

Dilution Calculator

Reconstitution Calculator

References for LNT 1

Product Documents for LNT 1

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

保持关注