Loreclezole hydrochloride

Name: Loreclezole hydrochloride
Brand: Tocris Bioscience
SKU: 1295

Tocris Bioscience, part of Bio-Techne | Catalog # 1295

Citations (3)

COA / SDS

Subtype-selective GABAA modulator

Key Product Details

Description:	Subtype-selective GABA_A modulator
Chemical Name:	(Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	311

View Full Technical Details for Loreclezole hydrochloride

Technical Data
Citations

Biological Activity for Loreclezole hydrochloride

Loreclezole hydrochloride is a subtype-selective GABA_A receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABA_A receptor sensitization. Inhibits homomeric ρ1 GABA_C receptors.

Technical Data for Loreclezole hydrochloride

M. Wt	311
Formula	C₁₀H₆Cl₃N₃.HCl
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	2227372-56-5
PubChem ID	45073437
InChi Key	AWKSVFLKVCVVFQ-MDZFRNKHSA-N
Smiles	Cl[H].Cl\C(=C/N1C=NC=N1)C1=C(Cl)C=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Loreclezole hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	1.37	5 with gentle warming
	ethanol	1.37	5 with gentle warming

Preparing Stock Solutions for Loreclezole hydrochloride

The following data is based on the product molecular weight 311.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	64.31 mL	321.54 mL	643.09 mL
0.25 mM	12.86 mL	64.31 mL	128.62 mL
0.5 mM	6.43 mL	32.15 mL	64.31 mL
2.5 mM	1.29 mL	6.43 mL	12.86 mL

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References for Loreclezole hydrochloride

References are publications that support the biological activity of the product.

Thomet Loreclezole as a simple functional marker for homomeric ρ type GABA_C receptors. Eur.J.Pharmacol. 2000 PMID: 11080529
Fisher Loreclezole inhibition of recombinant α1β1γ2L GABA_A receptor single channel currents. Neuropharmacology 2000 PMID: 10670419
Smith Compounds exhibiting selective efficacy for different β subunits of human recombinant γ-aminobutyric acid_A receptors. J.Pharmacol.Exp.Ther. 2004 PMID: 15210837
Donnelly and Macdonald Loreclezole enhances apparent desensitisation of recombinant GABA_A receptor currents. Neuropharmacology 1996 PMID: 9014138